Samsom lab

Pediatric Gastroenterology & Nutrition

People Samsom Lab

Janneke N. Samsom (PI)

Janneke performed her PhD research on host defense to Listeria monocytogenes infections in Leiden with Ralph van Furth. After a brief postdoc on respiratory viruses at the institute for Livestock research in Lelystad she joined the lab of Georg Kraal at the VU Medical Center where she identified mechanisms of regulatory T cell induction that drive nasal and oral tolerance to harmless antigens and started her own research group. In 2005 she moved to Rotterdam to combine her fundamental mucosal tolerance research with translational research of the pathogenesis of celiac disease and inflammatory bowel disease, disorders caused by loss of mucosal tolerance to harmless food and bacterial antigens respectively. In 2013 she became head of the entire laboratory of Pediatrics.

Sandrine Nugteren
(MD, PhD student)

Sandrine initiated her studies at the Erasmus MC in Rotterdam where she received her medical degree in 2014 and finished a research master in Infection and Immunity in 2015, both with “cum laude” distinction. During her research master she focused on various aspects of innate intestinal immune regulation, starting in Janneke Samsom’s lab and finishing with an internship in the lab of Kevin Maloy at the University of Oxford. Thereafter she performed a short project on the role of the protein Secretory Leukocyte Protease inhibitor (SLPI) in wound healing in the lab of Mark Coles at the University of York.  In 2015 Sandrine started as pathologist-in-training in the Erasmus MC and in January 2017 she joined Janneke Samsom’s lab again for a PhD on the role of SLPI in intestinal inflammation and colorectal carcinoma.

Myrthe Jongsma
(MD, PhD student)

Myrthe graduated as medical doctor from Leiden University in 2016. She worked as a resident at the department of pediatrics in Nijmegen, where after she started as PhD student on the TISKIDS trial in April 2017. This trial is a collaboration between the department of paediatric gastroenterolgy and Janneke Samsom’s lab. The main focus of this project is to optimize treatment strategy for paediatric Crohn’s disease patients with moderate-to-severe disease.

Maud Heredia
(PhD student)

Maud graduated as a Master in Molecular and Cellular Biology, with a specialisation in Immunology, from Sorbonne University, Paris, in 2019. She joined the lab the same year as a PhD-student, focusing on the role of inflammatory and regulatory T cell responses in inflammatory bowel disease (IBD). She has been mainly working with patients materials, performing flow cytometry experiments and analysing flow cytometry data that have been collected throughout the patients visits.

Renz Klomberg
(MD, PhD student)

Renz graduated as a Medical Doctor at the Utrecht University in November 2017. He worked as a resident in pediatrics at the Juliana Children’s Hospital in The Hague for one year. In 2019 he moved to Surinam to work as a resident in pediatrics at the Academic Pediatric Center of Surinam. He started his PhD at the Erasmus Medical Center / Sophia Children’s Hospital in January 2020. His research focuses on the identification of both clinical and immunological markers of (complicated) disease course and (non-)response to therapy in pediatric IBD patients. He coordinates the PIBD SETQ inception cohort study, an international study with over 25 centers worldwide. Moreover, he is involved with the translational research of the Samsom lab within this cohort. His research is under daily supervision of L. de Ridder and J. N. Samsom.

Daniëlle Barendregt
(PhD student)

Daniëlle finished her BSc Biomedical Sciences at Leiden University in 2017. After this she continued her studies with a research master Biomedical Sciences at Leiden University and a master Philosophy, Bioethics and Health at the VU Amsterdam. During her biomedical studies she focused on immunology and did internships in the fields of pediatric immunology and tumor-immunology. In June 2020 Daniëlle started her final master internship in the Pediatric Gastroenterology and Nutrition group of Janneke Samsom, with daily supervision by Maud Heredia. She works on the function of the regulatory molecule TIGIT, which might play a role in IBD.

Ytje Simons-Oosterhuis
(research technician)

Ytje graduated from the Utrecht University of Life Sciences & Chemistry in 2003. In that same year she joined the lab as a research technician. In the group Ytje has set up the broad repertoire of molecular techniques essential for all lines of research. Moreover, her main line of investigation concerns the role of the NF-kB inhibitor secretory leukocyte protease inhibitor (SLPI) in intestinal homeostasis. Over the years Ytje has been involved in practical training of multiple Master/PhD students and postdocs.

Lisette A. Van Berkel
(research technician)

Lisette graduated as a Master in Medical Biology from Leiden University in 2000. She joined the Samsom group in Amsterdam in 2000. She has set up all murine models for mucosal tolerance and intestinal inflammation and is responsible for implementing all new developments in flow cytometry. In 2005 she moved with the group to Rotterdam to continue the basic research line on intestinal tolerance. Lisette is an essential contributor to all lab projects containing murine models and/or flow cytometry and as such also trains Master/PhD students and postdocs.

Daniëlle van Haaften
(research technician)

Daniëlle graduated from the Utrecht University of Life Sciences and Chemistry in 2018. She joined the research group earlier for an internship from 2017 until 2018. During her internship, she worked on the role of gluten degradation and IL-10 regulation in the development of celiac disease. Daniëlle stayed with the group after graduating as a research technician. Nowadays, she is involved in patient studies for Inflammatory Bowel Disease (IBD) as well as celiac disease. Next to that, Daniëlle contributes to lab projects containing histological and immunohistochemical techniques.

Bastiaan Tuk
(research technician)

Bastiaan graduated as laboratory technician with a specialization in Microbiology in 2005 at the Zadkine college in Rotterdam. Before joining the Samsom lab, Bastiaan has worked as research technician for the department of Reconstructive surgery at the ErasmusMC. In this 12 year period, Bastiaan has been involved in different research topics ranging from wound-healing, decubitus, diabetic ulcers, psoriasis as well as nerve regeneration. His field of expertise has been immuno-histochemistry and organ on a chip development in collaboration with the Technical University-Delft. Over the years, Bastiaan has trained multiple master/PhD students and post-docs. In 2019, he joined the Samsom lab, where he is part of the multidisciplinary team responsible for all patient related laboratory work involving a wide variety of laboratory techniques.

Brenda Bley Folly
(PhD, project manager)

Brenda graduated as a Master in Molecular Biology in 2009, in the Federal University of Paraná, in Brazil. She moved to the Netherlands in 2013, where she obtained her PhD in Molecular Systems Biology in the University of Groningen, in 2018. In 2017, she started working as research project manager in the same university. In her first project, she was responsible for managing an EU Horizon2020 ITN Consortium. In 2019, she the Samsom laboratory, as the research project manager of the TIMID consortium, funded by Health Holland and SGF. Together with Janneke Samsom, Brenda is the responsible for the coordination of all non-scientific aspects of TIMID.

Kirsten Roggeband
(master student)

Former Colleagues

Mariëtte ter Borg
Sylvia Brugman
Lea Costes
Maarten Cozijnsen
Jolanda van Dieren
Colin de Haar
Jeroen Hol

Linda Joosse
Anita Korteland-van Male
Anne Kozijn
Margaretha Lambers
Marieke van Leeuwen
Pieter van Lierop
Dicky Lindenbergh-Kortleve

Kit-Yeng Liu
Celia Menckeberg
Sabine Middendorp
Edward Nieuwenhuis
Fleur du Pré
Rolien Raatgeep
Lilian de Ruiter

Irma Tindemans
Krisztina Truta
Sharon Veenbergen
Dwight Winter